NMR study of gallstones from benign and malignant gallbladders
Srivastava M, Nagana Gowda G, Gupta A, Sharma A, Kapoor V, Khetrapal C
Department of Surgery, Centre of Biomedical Magnetic Resonance
Gallstones from chronic cholecystitis (CC) (n=23; benign), xanthogranulomatous cholecystitis (XGC) (n=11; benign), and gallbladder cancer (GBC) (n=11; malignant) were studied using 1H NMR to explore aetio-pathophysiology of gallbladder cancer. Significantly less cholesterol and high calcium were observed in GBC compared to CC (p<0.0001; p<0.002, respectively) or XGC (p <0.0001; p<0.03, respectively). Magnesium was high in GBC compared to CC (p<0.002). Striking differences in the gallstone composition of the malignant and benign patients that can be obtained rapidly from single pulse NMR methods may provide new insights into the aetio-pathophysiology of gallbladder cancer.