Dynamic Contrast Magnetic Resonance Imaging Detects Premalignant High-Grade Dysplasia In Epithelial Carcinogenesis
Garbow J, Arbeit J, Engelbach J, Olson K
The ability to study and biologically characterize high-risk pre-malignant epithelial lesions of internal organs will be a tremendous boon to therapy and prevention of invasive malignancies. Here we used dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) to determine differential microvascular biology associated with neoplastic progression in a unique transgenic mouse model of multistage cervical carcinogenesis. Vascular permeability (KPS), measured at the cervical transformation zone using DCE-MRI, is approximately 50% greater in transgenic animals displaying high-grade squamous epithelial dysplasia compared with non-transgenic animals. Sub-epithelial microvascular area, measured from MECA32 immunoperoxidase stained tissue sections, was similarly elevated in the transgenic animals.