Differentiation of Low from High Grade Oligodendrogliomas by 1H Magnetic Resonance Spectroscopy Imaging and Perfusion Weighted Imaging
Wang J, Wolf R, Melhem E, Poptani H, Wang S, Chawla S, Woo J, Grady M, Judy K, O' Rourke D
University of Pennsylvania
The study was performed to ascertain whether combined use of CASL and 1H-MRSI can differentiate low from high-grade oligodendrogliomas. 1H-MRSI and CASL imaging was performed on eleven patients. Average CBF from solid parts of the tumor were normalized to contralateral white matter and assigned as CBFT/W. Absolute concentrations of metabolites from these regions were normalized to contralateral white matter. Although CBF T/W could not differentiate between high-grade and low-grade oligodendrogliomas, 1H-MRSI exhibited high ChoT/W and Lip/Lac T/W in high grade-III tumors than grade-II oligodendrogliomas suggesting a complementary role of the two MR techniques.