TOOKAD Photodynamic Therapy of orthotopic PC3-MM2 prostate tumors in nude rats : investigation using BOLD-MRI, Diffusion-weighted-MRI and Dynamic-Contrast Enhanced MRI
Ficheux H, Just N, Guilbaud N, Blanc D
Photodynamic therapy (PDT) of cancers is a physico-chemical method for the local treatment of cancers and some other vascular diseases. PDT represents a unique therapeutic means of treating patients that cannot undergo other classical therapies either for operatory contraindications or inefficacy of radiotherapy and chemotherapy. In this study, Tookad PDT was investigated with both invasive and non-invasive techniques to determine the best conditions for appropriate PDT therapy of xenografted human prostate tumors. MRI techniques allowed early determination of tumor response to treatment , informations that may be useful for further clinical investigations of prostate cancer response to Tookad PDT treatment.