Abstract #1781

Amans M, Guthikonda M, Barger G, Xuan Y, Zamorano L, Sehgal V, Hu J, Jiang Q, Hm-Meeran S

Glutamine (Gln) and glutamate (Glu) levels are both directly and indirectly (via reactive oxygen species signaling) involved in tumor proliferation and apoptosis, and thus could provide useful information for tumor diagnosis and treatment. Preliminary results demonstrate a consistent and remarkable increase in both Gln concentration (using water as a reference) and Gln/Cr ratio. The results also suggest Gln/Glu could be an early indicator of malignant transformation compared to ""traditional"" 1H MRS markers such as NAA, Cho, and Cr.