Diffusion is a Major Determinant of Contrast in SSFP-Based Single Cell MRI: A Theoretical and Experimental Study
Rutt B, Heyn C, Wade T, Foster P, Rutt D
Robarts Research Institute
In cellular imaging, the static dephasing model of the FIESTAsequence consistently underestimates the signal loss. A new model,based on the theory developed by Kaiser for signal loss in a SSFP sequence due to diffusion, has been modified for theFIESTA sequence to estimate the signal from each subvoxel in animaging voxel. This new model, which includes both dephasing anddiffusion effects, has proved very effective at predicting thesignal from voxels containing iron loaded cells.