Off Resonance Spectroscopic Imaging of Iron Oxide Nanoparticles at Dilute Concentrations and High Field Strengths
Sosnovik D, Rosen B, Dai G, Farrar C
Massachusetts General Hospital
Off Resonance Spectroscopic Imaging (ORSI) may provide a powerful new technique for bright contrast imaging of susceptibility based contrast agents. Prior studies with ORSI have been done at 1.5 Tesla and with high concentrations of the contrast agent. The aim of this study was thus to evaluate ORSI at high field strengths and dilute concentrations of iron oxide. Our results suggest that ORSI may be able to (1) selectively image different MION concentrations, (2) selectively suppress susceptibility based artifacts such as air bubbles, and (3) detect MION concentrations as low as 8 ug Fe/ml in fluid solution.