Selective MRI and MRS of PEGylated Compounds
The University of Michigan
To reduce clearance time, delay breakdown time, and increase clinical efficacy, small molecule pharmaceutical agents are sometimes attached to polyethylene glycol (PEG). We report that PEGylated pharmaceuticals can be selectively detected using MRI or MRS with an increased sensitivity of up to three orders of magnitude. High molecular weight, flexible polyethylene chains, and superposition of many ethylene resonances combine to create a condition favorable for MRI and NMR detection. In this example we have selectively created an image Pegaptanib Sodium with only 32 nmoles of compound.