Novel Myristoylated Polyarginine Peptides for Molecular Neuroimaging: Initial In Vivo Studies
Pham W, Van Buchem M, Nabuurs R, Dai G, Moore A
Massachusetts General Hospital
Recently we have demonstrated that a fluorescently labeled myristoylated polyarginine peptide, MPAP, could cross the blood-brain barrier and be detected by in vivo optical imaging. This study assessed whether a gadolinium-modified delivery module, MPA11P, could cross the BBB and could be detected by MRI. In vivo MRI was performed using a T1 inversion recovery sequence on nude mice before and after intraperitoneal administration of MPA11P. T1 histograms of manually segmented brain regions showed a peak shift towards a lower T1 time 24 h after injection. Our study suggests that MPA11P-Gd could be detected in the brain by in vivo MRI.