Comparison of labeling strategies for stem cells with Gd-chelates.
Himmelreich U, Geelen T, Justicia C, Strecker C, Hoehn M
Max-Planck-Institute for Neurological Research
Gd-chelates are suitable for the visualization of deposits of stem cells in vivo. The route of internalization of Gd-chelates influences the efficiency of the labeling and the detectability of cells. Electroporation was most efficient for the three cell lines used in the study. Saturation of R1 relaxivity was observed for cells that took up Gd-chelates by endocytosis.