High Resolution 2D and 3D Magnetic Resonance Imaging of Murine Carotid Arteries In Vivo
Zernecke A, Flgel U, Jacoby C, Schrader J, Weber C, Aurich V, Bhring Y, Beck A
Rheinisch-Westflisch Technische Hochschule Aachen
This study was aimed at developing protocols for repetitive monitoring of vascular lesion development in murine carotid arteries in vivo. Using atherosclerotic mouse models, 2D and 3D high resolution MR measurements were performed at different time points before and after experimental injury in order to detect different courses of vascular remodeling depending on the degree of injury. MRI measurements were highly correlated to morphometric data obtained 4 weeks after injury. Additionally, high reproducibility as well as low intra- and interobserver variabilities were determined by repetitive measurements and analyses, respectively.