Longitudinal measurements of myocardial creatine content in normal and creatine transporter over-expressing mouse hearts using single voxel 1H-MRS in vivo
Phillips D, ten Hove M, Wallis J, Neubauer S, Schneider J
University of Oxford
In this study we used single voxel 1H-MRS to longitudinally measure the myocardial creatine content in normal and creatine transporter over-expressing mice at six weeks, four and eight months, respectively, and to reference it to the unsuppressed water signal. Using HLPC, we previously showed that creatine transporter over-expressing mice have elevated but variable creatine levels. Now we demonstrate that cardiac 1H-MRS can be used in vivo to non-invasively quantify the myocardial creatine content, to stratify normal and genetically modified mouse hearts according to their metabolite levels, and to follow them longitudinally.