Treatment of Adolescent Bipolar Depression with Lithium: Effects on Brain MyoInositol Levels Measured by Proton MR Spectroscopy
Strakowski S, Patel N, Adler C, DelBello M, Cecil K
University of Cincinnati College of Medicine
This study used proton MRS to identify the effects of lithium on myo-inositol (mI) concentrations in adolescent bipolar depression. Twenty-eight adolescents with bipolar disorder, current episode depressed, received lithium, adjusted to achieve serum levels of 1.0-1.2 mEq/L. Medial, left and right lateral prefrontal mI concentrations were measured at baseline, day 7, and day 42 using short echo (TE 35 ms) MRS acquired at 1.5T. A significant change over time was observed for mI concentrations in the medial prefrontal cortex and right lateral prefrontal white matter. Specifically, day 42 concentrations were significantly higher than those on day 7 in both regions.