Assessing the Effect of Comorbidity in Attention-Deficit/Hyperactivity Disorder (ADHD) Using In vivo 31P Spectroscopy
Kipp H, Keshavan M, Greisenegger E, Panchalingam K, Pettegrew J, Bukstein O, Stanley J
Western Psychiatric Institute and Clinic
Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent neurodevelopmental behavioral disorders. A preliminary in vivo phosphorus (31P) spectroscopy study has shown deficits in membrane phospholipid (MPL) precursor levels in the basal ganglia (BG) and prefrontal (PF) regions of children with ADHD compared to healthy control subjects. The purpose of this study is to assess the effect of comorbid oppositional defiant disorder (ODD) and/or conduct disorder (CD) on MPL deficits. Results show greater MPL deficits in ADHD subjects with greater severity in behavioral symptomatology.