Using rCBV and CBF to Distinguish Radiation Necrosis from Tumor Recurrence in Malignant Gliomas
Lund R, Rand S, Schmainda K, Krouwer H, Schultz C
Medical College of Wisconsin
Distinguishing radiation necrosis from tumor recurrence is a key aspect of post-radiation follow-up in patients with malignant gliomas. An area of enhancement on MR could represent necrosis of surrounding tissue or tumor recurrence. The aim of the study was to determine if relative cerebral blood volume (rCBV) and cerebral blood flow (CBF) imaging could distinguish between viable tumor and radiation necrosis. The SE rCBV showed a significant difference between normalized rCBV values for low-grade gliomas and radiation necrosis. Both GE and SE CBF showed a significant difference between normalized CBF values for low-grade gliomas and radiation necrosis.