MRI Evidence For A Strong Relationship Between Total Cerebral White-Matter Lesion Load And Clinical Disability In Patients With Multiple Sclerosis
Caramanos Z, Arnold D, Narayanan S, Francis S, Matos A, Tartaglia M, Lapierre Y
Montreal Neurological Institute, McGill University
We examined the cross-sectional relationship between clinical disability and total cerebral white-matter lesion load (LL) in a large sample of patients with multiple sclerosis. We found that LLs (particularly T1-LLs) are strongly related to clinical disability when patients that span a wide range of clinical disability are examined. Our results also suggested that in combination with their mean cervical-cord cross-sectional area, disease duration, and sex such patients T1-LLs can account for a large degree of the variance in their clinical disability.