Identification of Abnormal White Matter in Multiple Sclerosis
Datta S, Mogatadakala K, Narayana P, Wolinsky J, Poonawalla A, Hasan K
University of Texas Medical School at Houston
The presence of so called normal appearing white matter (NAWM) which appears normal on conventional magnetic resonance imaging (MRI), but is abnormal, is well recognized in Multiple Sclerosis (MS). It is thought that NAWM represents tissue at risk. However, currently, there are few noninvasive techniques for identification of the NAWM. We present a technique that is based on a combination of multi-parametric segmentation of MRI and fractional anisotropy (FA) derived from the diffusion tensor imaging (DTI) in identifying the NAWM.