The Effect of Slice Thickness on Assessment of Atherosclerosis Geometry Measures
Rapp J, Wong G, van Tyen R, Gelombickaite R, Saloner D
VA Medical Center
This study was performed to assess the impact of reduced resolution, such as is attainable in clinically-relevant studies, on the assessment of plaque geometry. Measurements of plaque volume were made with standard in vivo imaging method on six excised carotid endarterectomy specimens. This was compared with measurements made using ultra-high resolution imaging. Measurement of plaque volume and maximal wall area made with 2mm thick slices was found to be in good agreement with that made with the 0.2mm slices. This indicates that studies with 2mm thick slices are sufficient for monitoring changes in plaque bulk over time.