Biliary Enhancement of Gd-BOPTA (MultiHance) and Gd-EOB-DTPA (Primovist) - a Study in Healthy Volunteers
Albiin N, Smedby , Dahlstrm N, Persson A, Brismar T
Karolinska University Hospital Huddinge
Contrast media that give intraluminal enhancement in the biliary system can provide functional information. In this study the dynamics of bile duct enhancement relative to that of liver parenchyma for Gd-BOPTA (Multihance) and Gd-EOB-DTPA (Primovist) was investigated. Ten healthy subjects were repeatedly examined after administration of each agent for five hours. The earlier onset of biliary enhancement and the longer duration of high image contrast between bile and liver with Gd-EOB-DTPA compared to Gd-BOPTA may facilitate the hepatobiliary examination at MRI. Near its biliary enhancement peak, Gd-BOPTA may however provide higher image contrast than Gd-EOB-DTPA within a short time window.