in vivo Sodium Imaging of Mouse Kidney at 9.4 Tesla: A Feasibility Study
Garcia M, Shen X, Hargreaves R, Williams D, Kohler M, Liu H
Merck Research Labs
High resolution in vivo sodium images of mouse kidney were obtained using a 9.4T NMR scanner in 20min. Both spatial resolution and SNR of the sodium images were sufficient for resolving the sodium concentration gradient at organ level and its change after a 15mpk flurosemide injection in mouse kidney. The result of the study suggests that such a non-invasive imaging based assessment can be used to gain insights regarding to renal function and mechanism of diuretics.