Magnetic Resonance Imaging Measurement of Renal Blood Flow Determined On First Pass Gadolinium-Chelate Perfusion
Jones R, Votaw J, Martin D, Sharma P, SALMAN K
Children's Healthcare of Atlanta
This study focuses on measuring renal blood flow from first-pass Gd-chelate perfusion imaging. The motivation is that both renal blood flow and glomerular filtration rate can be determined in one study session. The analysis assumed no contrast agent had reached the renal vein, making the window of perfusion analysis about 7 secs. By measuring the concentration of Gd in the kindey and artery over time, flow can be determined via a two-compartment kinetic model. Results show high correlation between this model and first-pass renal perfusion data. The method was validated against traditional phase contrast imaging.