Cardiac / respiratory double triggering for 1H MR spectroscopy of the liver
Kreis R, Vermathen P, Boesch C, Ith M, L K, Tappy L
Since intrahepatocellular lipid [IHCL] content is related to insulin sensitivity, studies of the metabolic syndrome often rely on a reliable and non-invasive determination by MR methods. IHCL content was measured with a cardiac/respiratory double triggering sequence that is based on the respiratory amplitude modulation of the ECG signal. Reproducibility was investigated for IHCL and TMA. The method proved sensitive and reliable enough to show a correlation between IHCL content and hepatic, as well as whole body, insulin sensitivity even in a small number of healthy non-obese subjects.