Effect of Chemical Exchange on T1 Values Calculated using DESPOT1
Rutt B, Deoni S, Jones D
Robarts Research Institute
In this work we investigate the effect of chemical exchange, such as between the intra and extracellular compartments in human brain white and grey matter, on T1 measurements made using the DESPOT1 (Driven Equilibrium Single Pulse Observation of T1) T1 mapping method. We show that, as can be anticipated, derived measurements have a strong dependence upon acquisition parameters, such as TR and flip angle. In comparison with inversion-recovery measurements, we demonstrate an increased sensitivity to fast T1 components of the DESPOT1 approach, suggesting its utility in imaging applications focused on these components.