Optimization of voxel based relaxometry parameters for the detection of focal T2 changes
Pardoe H, Pell G, Abbott D, Jackson G, Briellmann R
Brain Research Institute
The voxel-based approach has become a popular method for the analysis of various MR parameters between subject groups. The extension of the method to T2 analysis is termed voxel-based relaxometry (VBR). There are a considerable number of parameter choices to be made when setting up the analysis which may influence the outcome of the analysis. These include the choice of smoothing kernel and the warping procedure through which the images are registered to a standard space. This report examines the sensitivity of the analysis to these parameter choices in a study of a group of patients in which a focal area of T2 increase is expected.