ProFit: Two-Dimensional Prior-Knowledge Fitting of J-Resolved Spectra
Schulte R, Boesiger P
University and ETH Zurich
A two-dimensional fitting procedure is introduced, capable of extracting the full amount of information from 2D J-resolved magnetic resonance spectroscopy data. The fitting procedure uses a linear combination of 2D model spectra. In-vitro and in-vivo experiments on a whole-body 3T MR scanner show the detectability of a wide range of metabolites in the human brain, namely total creatine, N-acetyl aspartate, choline-containing compounds, glutamate, myo-inositol, glutathione, scyllo-inositol, &[gamma]-aminobutyric acid, alanine and ascorbic acid.