Quantitative Aspects of Measuring Contrast Reagent Extravasation in the Healthy Human Brain
Li X, Springer C, Rooney W
Oregon Health & Science University
A sufficiently high magnetic field (>4T) allows detection of extravasation of the common Gd(III) contrast reagents (CRs) in the normal human brain. [This is not caused by the greater field strength.] We use simulations to investigate aspects of Dynamic-Contrast-Enhanced (DCE) MRI experimental design that allow precise and accurate measurement of this.