Sensitivity and Detectability of Regional Differences in CASL Perfusion Between Subject Groups
O'Gorman R, Williams S, Alsop D, Zelaya F
King's College Hospital, Institute of Psychiatry
Despite a growing number of investigations of cerebral perfusion in various subject groups using ASL, the sensitivity and detectability of differences in absolute perfusion between groups have not been systematically assessed. In this study, the detectability of regional differences in ASL perfusion was investigated by implanting computer-generated perfusion increases into resting-state CASL perfusion images for one of two age-matched groups of healthy volunteers. The limits of detection for the implanted perfusion changes varied widely across brain regions, from 10 ml/min/100ml for clusters in the putamen to 30 ml/min/100ml for clusters in frontal white matter.