Resting-State Functional Connectivity Measured by VASO and BOLD
Yang Y, Gu H, Stein E
National Institute on Drug Abuse, NIH
Synchronized low-frequency fluctuations in resting-state fMRI signal have been used to study functional connectivity. So far, BOLD contrast has been the dominant technique for resting-state fMRI, although ASL perfusion imaging has been used in a few studies. Since BOLD signal arises from the complex interplay of blood flow, blood volume and oxygen consumption, the relationship between resting-state fMRI signal and each of these physiological parameters is not clear. In this study, we attempted to use a blood-volume based fMRI contrast to examine the dependence of resting-state fMRI signal on a single physiological parameter.