An analysis of micro- and macro-vasculature blood flow characteristics during graded stimulation
Ho Y, Golay X, Petersen E
National Neuroscience Institute, Nanyang Technological University
Using a recently developed arterial spin labeling (ASL) model-free method with and without crusher gradients to obtain information on both macro- and microvascular blood flow, it was observed that with an increase in contrast in visual stimulation, both arterial and microvascular arrival times were significantly shortened while cerebral blood flow and arterial blood volumes were increased. CBF increases were relatively muted compared to the stark changes in flow velocities. These results pose interesting questions and also have implications for CBF quantification.