DCE MRI Detected Differential Response to ZD6126 of Metastatic versus Indolent Human Melanoma
Zhou R, Li X, Hendrix M, Glickson J, Qiao H, Wachsberger P, Springer, Jr C, Li L
University of Pennsylvania
It has been previously demonstrated that metastatic melanoma (C6181) forms its own blood vessels through a vasculogenic mimicry mechanism . ZD6126, which targets the microtubular cytoskeleton of endothelial cells, is shown to induce vascular shutdown leading to tumor necrosis [2, 3]. We hypothesized that metastatic melanoma may have a more immature vasculature, which is more sensitive to ZD6126 treatment. We utilized DCE MRI to study the acute response (within 1 hr after treatment) and found that Ktrans of the metastatic melanoma was reduced over 60% (P<0.05) in response to ZD6126 injection, whereas Ktrans of the indolent tumor remains unchanged.