Incorporation of Explicit Arterial Input Function for DCE-MRI Quantification: Use in Human trial of Sorafenib in Renal Cell Carcinoma
Rosen M, Flaherty K, Schwartz B, Heitjan D, O'Dwyer P
University of Pennsylvania
We demonstrate the effects of incorporating a measured arterial input function (AIF) in DCE-MRI quantification, using the results of a recently completed human trial of DCE-MRI to monitor early response of renal cell carcinoma to Sorafenib. Use of a measured, rather than assumed, AIF leads to dramatic alterations in the resulting tumor Ktrans values before therapy. Change in tumor Ktrans following treatment is significantly associated with clinical outcome (time to tumor progression) only when the measured AIFs are utilized.