J-Resolved Proton Echo Planar Spectroscopic Imaging of GABA in the Human Brain
Renshaw P, Frederick B, Jensen J
McLean Hospital, Harvard Medical School
Two-dimensional, J-resolved magnetic resonance spectroscopy (2D, JMRS) has been combined with proton echo-planar spectroscopic imaging (PEPSI) to drastically reduce the required scan time needed to sample enough k-space and TE-points to adequately resolve and quantify the gamma-amino butyric acid (GABA) resonance sideband at 2.95ppm from neighboring creatine (Cr) at 3.03ppm at 4 Tesla. This combination of techniques allows us to either drastically reduce the scan-time needed to acquire a whole J-resolved PEPSI (JEPSI) dataset at a modest spatial resolution of 16x16, or to vastly increase spatial resolution to 32x32 in a clinically-sound scan time.