Water and Metabolite-Modulated MR Spectroscopy and Spectroscopic Imaging
Sacolick L, Rothman D, de Graaf R
An improved method for the simultaneous detection of water and metabolites is described that robustly eliminates spectral contamination from gradient-vibration-induced water sidebands. While the upfield region of the MR spectra is indistinguishable from regular water-suppressed MR spectra, the down-field region shows many enhanced resonances from slowly exchanging protons. The technique is also implemented with MRSI where the water resonance is used for automated frequency and B0 correction and phasing of spectra.