Histogram Analysis of Relative Cerebral Blood Volume Measurements in Cerebral Gliomas: An Interobserver and Intraobserver Reproducibility Study
Young R, Pollack E, Babb J, Johnson G, Law M, Pivawer G
NYU Medical Center
Dynamic susceptibility contrast perfusion MR imaging (DSC MRI) of gliomas is most commonly analyzed using region-of-interest (ROI) measurements. We compare inter- and intra-observer reproducibility for different techniques of measuring relative cerebral blood volume (rCBV) metrics using both ROI and non-ROI techniques. Routine rCBVmax ROI is compared with rCBVT tumoral and rCBVP peritumoral ROI as well as rCBVTT total tumoral non-ROI. Total tumoral histogram analysis, a non-ROI method, achieved the lowest coefficient of variation and highest between and within reader reproducibility. Further refinement of non-ROI analysis of perfusion MR data may lead to standardized, automated techniques for analyzing perfusion MR data.