Apparent Diffusion Coefficient Predicts Survival in a Transgenic Model of Glioma
Ross B, Holland E, Kreger A, Elliott W, Leopold W, McConville P, Moody J
University of Michigan
MRI was used to measure tumor volume and apparent diffusion coefficient (ADC), and compared with survival in the tv-a transgenic model of glioma. Mice with high grade gliomas were divided into two groups: vehicle control (n=12) and temozolomide treated (qdx5; 100 mg/kg IP; n=13). In the treated group, ADC showed a robust early increase that correlated with later tumor growth inhibition and was predictive of an eventual survival increase, compared with controls.