Assesing the response of pre-clinical tumor models to anti-neoplastic therapies using functional diffusion mapping (fDM)
Moffat B, Hall D, Chenevert T, Ross B, Hoff B
University of Michigan
The purpose of this study was to develop a new method for quantifying therapeutic induced changes in ADC maps of orthotopic rodent tumors. This is a departure from the traditional quantification of mean tumor ADC that does not adequately describe the heterogeneity of change in ADC that usually results from anti-neoplastic therapies. FDM enables segmentation tumors into regions response and resistance to therapy. The results significantly correlate with chemotherapy dose and animal survival.