Fast 4D Metabolite Mapping of Hyperpolarized 13C Compounds using Multiple Echo 3D FIESTA
Perman W, Leupold J, Bhattacharya P, Lin A, Harris K, Ross B, Hennig J
Saint Louis Univeristy School of Medicine
The objective of this work was to develop a technique which will allow repeated measurements of spatial (3D imaging) and spectral (1D chemical-shift) distributions of a hyperpolarized 13C substrate in order to determine spatially localized metabolic kinetics (e.g. spatial distribution of tumor metabolism of 13C-pyruvate to 13C-lactate). A standard 3D FIESTA pulse sequence was modified for multi-nuclear and multiple gradient echo imaging (ME-3DFIESTA). We then imaged 13C-acetate and 13C-2-hydroxyethylacrylate (280 Hz chemical shift) and simultaneously hyperpolarized 13C-hydroxyethylpropionate and 13C-cis-fumarate to demonstrate the feasibility of using fast ME-3DFIESTA 4D imaging to provide spatially localized metabolic information on hyperpolarized substrates and products.