Is NMR spectroscopy a suitable tool in clinical microbiology?
Sorrell T, Robert V, Daniel H, Dolenko B, Himmelreich U, Somorjai R, Mountford C
University of Sydney
A supervised, hierarchical classification method was developed for the identification of pathogenic yeast isolates based on NMR spectra of cell suspensions. The method is extendable for new, emerging pathogens. Identification was rapid and robust to the sub-species level. In addition, a distance-based classification is able to distinguish unusual isolates from those available in a database, providing hereby a method to identify outliers.