Detecting LGN Activation in Human Using Quantitative Perfusion-based FMRI: A Feasibility Study
Lu K, Zangwill L, Liu T, Duncan R, Perthen J
University of California, San Diego
Although blood oxygen level dependent (BOLD) activation in human lateral genicuate nucleus (LGN) has been detected using functional MRI (fMRI), no perfusion activation in LGN has been reported yet. We demonstrate in this study that perfusion-based fMRI using arterial spin labeling (ASL) MRI can detect perfusion activation in LGN. Background suppression and physiological noise correction are needed in order to achieve necessary signal-to-noise ratio (SNR) to reliably discern activation.