Evaluation of Intra-Renal Oxygenation in Mice by BOLD MRI at 3.0T Human Whole Body Scanner
Li L, Ji L, Prasad P, Lindsay S
BOLD MRI technique has been used in non-invasive evaluation of intra-renal oxygenation levels under normal conditions and during physiological and pharmacological maneuvers at both 1.5T and 3.0T in humans and rats. In this study, we have extended these observations to mouse kidneys. Some disease models are available primarily in mice especially ones that involves genetic mutations. The preliminary data presented here were acquired on human whole body scanner using a custom designed 2 cm loop coil. The BOLD response in mice to the administration of furosemide is similar to that previously seen in human and rat kidneys.