Long-term reproducibility of apparent diffusion coefficient using hyperpolarized 3He MRI in healthy volunteers.
keson P, Diaz S, Casselbrant I, Piitulainen E, Wollmer P, Pettersson G, Peterson B, Magnusson P
Malm University Hospital
Hyperpolarized He diffusion MRI has been used to estimate the size of the lung alveoli. If a method is possible to use in a clinical setting is dependent of its reproducibility. The aim of the study was to examine the long term reproducibility of 3He ADC MRI in non-smoking healthy volunteers. The average mean ADC value for all subjects was 0.216, 0.217 and 0.218 cm2/sec at baseline, at 6 months and at 12 months respectively (NS). An intra-individual mean ADC variation of 0.97 to 4.1 % was found. The method seems robust enough for the evaluation of emphysema.