Morphological assessment in a transgenic Cacna1a knockin migraine mouse model using automatic segmentation of high-resolution whole brain MR
van der Weerd L, Kiihne S, Reiber J, Admiraal-Behloul F, Poelmann R, van den Maagdenberg A, Frants R, Hogers B, van der Ven R, van der Landen R, van Buchem M
Leiden University Medical Center, Leiden University
Migraine is a neurological paroxysmal disorder affecting up to 16% in the general population. Familial hemiplegic migraine type-1 (FHM-1) is an autosomal dominant subtype of migraine with aura caused by mutations in the CACNA1A gene. Recently, we generated a transgenic knockin mouse model of migraine containing a human pathogenic R192Q FHM1 mutation in the mouse Cacna1a gene. The purpose of this work was the phenotypical characterization of brain structures in our migraine mouse model, assessing volume and morphology of the cerebellar white matter and the brain ventricles.