USPIO-enhanced MRI at 7T in a mouse model of focal cerebral ischemia
Pialat J, Wiart M, Berthezene Y, Cho T, Moucharrafie-Naime S, Nighoghossian N
Hopital de la Croix-Rousse, Laboratoire Creatis UMR CNRS 5515, U630 Inserm
The purpose of our study was to evaluate the inflammatory response in a mouse model of focal cerebral ischemia with ultrasmall superparamagnetic iron oxide (USPIO). Two days post-injury, hypointense region was observed in the caudate putamen on the ischemic hemisphere and strongly hypointense region appeared also within the corpus callosum contralateral to the lesion. No signal change was noted in healthy animals with USPIO injection, nor in stroke-induced animals without USPIO injection. Although the mechanisms underlying the hyposignal need further pathological investigations, these abnormalities may account for a global inflammatory process with transcallosal migration of USPIO particles.