Deconvolution of Compartmental Water Diffusion Coefficients in Stroke Using DW-IR MEMRI
Nair G, Bouley J, Helmer K, Fisher M, Shazeeb M, Sotak C
Worcester Polytechnic Institute, University of Massachusetts Medical School
The mechanism of the decrease in apparent-diffusion coefficient (ADC) of water in the brain during cerebral ischemia is not well understood. We sought to separate and individually measure the relative contributions of intra- and extracellular water ADC changes during ischemia using Mn2+ as an intracellular MRI contrast agent. The ADCs measured showed a significant reduction in both intra- and extracellular ADC during cerebral ischemia.