Effects of correction of susceptibility distortion on DTI measures
Zhu T, Zhong J, Liu X
University of Rochester
Diffusion tensor imaging is becoming very important for studies of neurological disorders such as Alzheimers disease. DTI data are usually collected with an EPI sequence, which suffers from susceptibility distortion. Consequently, DTI results such as fiber tracking and FA values in specific areas can be mis-interpreted. We undistorted the DWIs collected from a 3T scanner using field maps then compared the DTI results generated from the original and corrected DWIs. Fiber tracking and index maps after correction show more fidelity than original ones. Measurements in corpus callosum show that FA values increase while FA variance reduces significantly after the correction.