A double bolus injection protocol improves the precision of Ktrans in clinical DCE-MRI analysis
Roberts C, Buckley D, Parker G
University of Manchester
To achieve high precision in quantitative dynamic contrast-enhanced MRI (DCE-MRI) analysis it is necessary to sample the arterial input function (AIF) and subsequent tissue time course with high temporal definition. Using simulations we explored the effects of mis-sampling both a single and double bolus AIF and resulting tissue uptake curves over a range of temporal resolutions on tracer kinetic analysis. Our study suggests that in DCE-MRI studies where temporal resolution is longer than 9 seconds, a double bolus injection protocol is beneficial in achieving greater precision of kinetic modeling parameters.