Reproducibility of Dynamic Susceptibility Contrast MR with Standard and Block-Circulant Deconvolution Matrix
Mainero C, Wu O, Zhang W, Sorensen A
Massachusetts General Hospital
Repetitive dynamic susceptibility contrast magnetic resonance imaging within hours is both potentially useful and feasible. The primary aim of this study is to determine the test-retest reproducibility of relative cerebral blood volume (rCBV) and flow (rCBF) acquired with the interval of half an hour. The secondary aim is to investigate the effect of different matrixes used for singular-value decomposition (SVD) with a single arterial input function (AIF) (sSVD) or a block-circulant matrix of AIF (oSVD), on the reproducibility of rCBF. Results showed good reproducibility of rCBV. The reproducibility of rCBF from oSVD was better than that from sSVD.