SIGNIFICANCE OF MYOCARDIAL ISCHEMIA IN HYPERTROPHIC CARDIOMYOPATHY: RELATION OF REGIONAL PERFUSION ABNORMALITIES TO LEFT VENTRICULAR HYPERTROPHY ASSESSED BY MAGNETIC RESONANCE IMAGING
Kramer H, Panse P, Hart C, Wilke N, Zenovich A, Jerosch-Herold M, Rickers C, Maron B
University Hospital Kiel
We hypothesized magnetic resonance perfusion imaging would allow more precise quantitative assessment of regional blood flow distribution in Hypertrophic Cardiomyopathy (HCM). Using first pass MR perfusion imaging we found that the cardiomyopathic process in HCM is most marked in hypertrophied regions of the LV. MR perfusion abnormalities were most prominent in hypertrophied compared to non-hypertrophied areas. Adverse consequences of HCM (i.e., sudden death and progressive symptoms), often associated with marked LVH may be due, in part, to myocardial ischemia.