Quantification of bone-water concentration in a 3T whole-body imager using solid-state imaging
Techawiboonwong A, Wehrli F, Song H, Fernandez-Seara M
University of Pennsylvania Medical Center
The majority of bone water resides in the microscopic pores of the lacuno-canalicular system, leading to extremely short T2 (~400 s). Imaging of bone therefore requires solid-state imaging (SSI) techniques. Here we hypothesized that bone water can be quantified and thus potentially pore volume determined in situ. As a model for varying pore volume we controlled H2O content by partial exchange with D2O. The SSI experiments on animal bone show that high measurement precision can be achieved at 3T and therefore in vivo quantification appears feasible.