Masako Yano Kataoka1, Andrew Nicholas Priest1, Martin J. Graves1, Ilse Joubert1, Robin Crawford2, Helena Earl3, James Brenton3,4, Mary A. McLean4, John R. Griffiths4, David J. Lomas1, Evis Sala1
1Radiology, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK; 2Obstetrics & Gynaecology, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK; 3Oncology, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK; 4Cancer Research UK, Cambridge Research Institute, Cambridge, UK
We evaluated the ADC values of primary ovarian, omental and peritoneal lesions in 16 patients with advanced ovarian cancer before and after neo-adjuvant chemotherapy. Baseline ADC values of peritoneal implants were considerably lower than that of primary ovarian lesions and significantly lower than those of omental cake. The primary ovarian tumours tended to have the highest ADC values which increased significantly after treatment. Our findings may reflect mixed treatment response that frequently occurs clinically at different sites of disease. This may be explained by variable blood supply and hypoxia which limits delivery and efficacy of chemotherapy at certain anatomical sites.